PhysioCue's Hypertension Therapy Devices externally stimulates carotid baroreceptors,
which are located within the carotid sinus in the neck, using our hand-held therapy device with our patented thermal neurostimulation.
Stimulation of the baroreceptors, at a precise temperature and duration, results in modulating the autonomic nervous system, stimulating the parasympathetic nervous system, and lowering the sympathetic drive, causing vasodilation and lowering of the heart rate.
The sum of these actions results in immediate lowering of blood pressure.
In PhysioCue's proof-of-concept pilot clinical trial, in a panel of 120 patients over 68 days, all patients lowered their systolic BP. Especially, 80% of the patients lowered their systolic BPs more than 10mmHg, which is equivalent to antihypertension drugs.
During the trial, a typical patient had a systolic BP of 176mmHg. After the patient's first 5-minute PhysioCue therapy session by day 61 days, BP dropped to 140mmHg. Furthermore, the patient's sustainable BP steadily remained with a total reduction of 36mmHg over 68 days.